Upsets happen, even by double-digit underdogs - and especially in the Michigan - Ohio State series. Former OSU head coach Jim Tressel picked up one of the Buckeyes' biggest with a 26-20 victory in Ann Arbor in 2001, but the Wolverines have picked up the biggest stunners in the rivalry.

Most point to 1969 and Bo Schembechler's 24-12 victory over Woody Hayes as the most surprising. Former OSU quarterback Rex Kern told Cleveland.com the sting has never left.

"For a while?" Kern yelled. "For a while? For a while?

"How about for a lifetime?"

Running back Jim Otis concurred.

"It still lingers," said running back Jim Otis. "It still bothers me."

The Buckeyes had beaten No. 10 Purdue, 42-14, a week before the loss and entered as a 15-point favorite - similar to this year's point spread.

"Whenever a team wins so easily and the point spread is so great, when you get into a tight ball game, even though it might be tied or you might be behind by maybe a field goal, you start thinking, 'Holy cow, we're getting beat.' And you start pressing."

Kern threw four interceptions, part of a seven-turnover day. Barry Pierson notched three of the picks and also returned a punt to the two-yard line to set up a score.

"We could've all had Superman outfits on and gone up there and there's no way we could've won that game with the [mistakes]," Otis said.

Michigan receivers watched clips of the 1969 game in preparation. The '69 Buckeyes were riding a 22-game win streak heading in. This year's edition has gone 23 straight without a loss and enters a 16-point favorite.

"The Michigan guys talk about how they really took it to us," Otis recalled. "Let me tell you something: I could still play against them. I could get out there right now and run over their [butts]."

Maybe. But it wouldn't change the outcome.

Here are Michigan's other significant upsets in the series:

This was an upset based on record only. Michigan was actually a one-point favorite in this game, but stood only 6-4. OSU, 0-4-1 in its last five, ran into a buzz saw on a frigid day in Ann Arbor. The Buckeyes were 9-0-1 and still in the race for a national title.

The Wolverines picked off four passes, got 105 rushing yards from Tyrone Wheatley and a circus, over the shoulder catch from Mercury Hayes - all in the first half.

"It's the most embarrassing game I think I've ever been associated with since I've been coaching college football," OSU's John Cooper said. "We got outplayed every way possible."

Running back Eddie Davis added 96 yards after Wheatley left with injury in the second quarter.

OSU's Eddie George, the eventual Heisman Trophy winner, came in with all the hoopla, but Michigan's Tshimanga Biakabutuka stole the show. The No. 2 Buckeyes were crushed by Biakabutuka's 313 rushing yards on 37 carries including a two-yard touchdown with 7:55 remaining that left the Buckeyes trailing by 16 points.

Freshman Charles Woodson provided the exclamation point with a late interception that stunned Ohio State again. Cooper said he'd never been more disappointed in his life.

"I've been playing football for six years, including high school, and I've never seen holes like that," Biakabutuka said. "Any one of you guys could have run through them."

The Michigan line sprung Biakabutuka for 22- and 19-yard gains on its first two snaps.

"We were able to just blow them off the ball," Michigan guard Joe Marinaro said. "The first play and the second play, we knew right away we could do that. You shouldn't be able to do that against any defense, especially the defense of the No. 2-ranked team in the country."

Ohio State entered a 17-point favorite over the underachieving Wolverines. Michigan entered as though it had been there before.

Chris Howard ran for 105 yard and Tai Streets took a slant pass 68 yards for a third-quarter touchdown that made it a two-point game. Remy Hamilton nailed a go-ahead 44-yard field goal and a clinching 39-yarder. Marcus Ray sealed it with an interception, sliding to the turf as time expired and holding the ball up for everyone in the stadium to see.

The Wolverines outgained Ohio State, 237-84, in the second half and limited the Buckeyes to five net yards rushing.

"I just think we're a better team," Woodson said.

They proved it in front of a stunned Buckeye contingent.